I successfully run an 80GB SATA Intel SSD with a SATA2SCSI module (on my A4000T/060), but finding these kinds of adapters today would be a challenge. I use <4GB of it, though.
I've set up a BlueSCSI and a ZuluSCSI with 128GB cards, and built ~32GB partitions on them (for a client using the Amiga for audio and video productions) - I would send you this direction if you just have to have that much disk space attached to the Amiga. I hope you have plenty of RAM if you plan to use FFS on it.
For backup purposes, with the above SD configuration, I feel that being able pull the cards out, and copy the image files off, is called piece of mind. I might also suggest a Network NAS for the home and/or use a wired network card and have less disk space on the Amiga. Aside from the A4000T (for test purposes), this smaller disk and network design is my preferred setup.