Expansion port is definitely not keyed on C64. I believe that most early CBM game cartridges (e.g. Le Mans) should work just fine on both systems, perhaps with some minor speed/sound related issues.
Newer releases, however, might show some unwanted glitches on overseas machines, mainly due to extensive use of raster sinchronized code, but a quick search for "pal/ntsc" on CSDB will show you 2000+ "fixed" titles.